Courses:

Chemical and Biological Reaction Engineering >> Content Detail



Study Materials



Readings

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Required Texts


Amazon logo Fogler, H. S. Elements of Chemical Reaction Engineering. 4th ed. Upper Saddle River, NJ: Prentice-Hall PTR, 2006. ISBN: 9780130473943.

There will also be reading from the manuscript of the forthcoming textbook Biological Kinetics by K. Dane Wittrup and Bruce Tidor.



Recommended Texts


Amazon logo Levenspiel, O. Chemical Reaction Engineering. 3rd ed. New York, NY: Wiley, 1999. ISBN: 9780471254249.

Amazon logo Smith, J. Chemical Engineering Kinetics. 3rd ed. New York, NY: McGraw-Hill, 1981. ISBN: 9780070587106.

Amazon logo Steinfeld, J. I., J. S. Francisco, and W. L. Hase. Chemical Kinetics and Dynamics. 2nd ed. Upper Saddle River, NJ: Prentice Hall, 1999. ISBN: 9780137371235.

Amazon logo Bailey, J. E., and D. F. Ollis. Biochemical Engineering Fundamentals. 2nd ed. New York, NY: McGraw-Hill, 1986. ISBN: 9780070032125.

Amazon logo Stephanopoulos, G., A. Aristidou, and J. Nielsen. Metabolic Engineering: Principles and Methodologies. San Diego, CA: Academic Press, 1998. ISBN: 9780126662603.



Readings by Session


Instructors:
WHG = William H. Green
KDW = K. Dane Wittrup


SES #TOPICSREADINGS
L1Preliminaries and remembrance of things past. Reaction stoichiometry, lumped stoichiometries in complex systems such as bioconversions and cell growth (yields); extent of reaction, independence of reactions, measures of concentration. Single reactions and reaction networks, bioreaction pathways. (WHG)
L2The reaction rate and reaction mechanisms: Definition in terms of reacting compounds and reaction extent; rate laws, Arrhenius equation, elementary, reversible, non-elementary, catalytic reactions. (WHG)Fogler, sections 1.0-1.4.1 and 3.0-3.5.
R1Recitation 1
L3Kinetics of cell growth and enzymes. Cell growth kinetics; substrate uptake and product formation in microbial growth; enzyme kinetics, Michaelis-Menten rate form. (KDW)

Fogler, sections 7.2 and 7.4.0-7.4.4.

"Enzyme Kinetics." Chapter 6 in Biological Kinetics.

L4Kinetics of cell growth and enzymes. Cell growth kinetics; substrate uptake and product formation in microbial growth; enzyme kinetics, Michaelis-Menten rate form. (KDW)Fogler, section 7.1.
R2Recitation 2
L5Continuous stirred tank reactor (CSTR). Reactions in a perfectly stirred tank. Steady-state CSTR. (KDW)Fogler, sections 1.4.1, 2.1, 2.3.1, 2.4, 2.5, 4.1, and 4.2.1.
L6Concentration that optimizes desired rate. Selectivity vs. Conversion. Combining reactors with separations. (WHG)Fogler, sections 6.0-6.4 and 6.6.
R3Recitation 3
L7Batch reactor: Equations, reactor sizing for constant volume and variable volume processes. (KDW)Fogler, sections 1.2, 1.3, 1.5, 2.1, 2.2, 4.1, and 4.2.1.
L8The plug flow reactor. (WHG)Fogler, sections 1.4.2, 1.4.3, 2.1, 2.2.2, 2.3 (PFR), 2.4 (PFR), 3.3.3, 3.3.4, 3.4, 3.5, 4.3, and 4.4.
R4Recitation 4
L9Reactor size comparisons for PFR and CSTR. Reactors in series and in parallel. How choice of reactor affects selectivity vs. conversion. (KDW)Fogler, sections 2.2, 2.3, 2.4, 2.5, and 4.7.
L10Non-ideal reactor mixing patterns. Residence time distribution. Tanks in series model. Combinations of ideal reactors. (KDW)Fogler, sections 13.1-13.4, 14.2, and 14.7.
R5Recitation 5
L11Non isothermal reactors. Equilibrium limitations, stability. Derivation of energy balances for ideal reactors; equilibrium conversion, adiabatic and nonadiabatic reactor operation. (WHG)Fogler, sections 8.0-8.8.
L12Data collection and analysis. Experimental methods for the determination of kinetic parameters of chemical and enzymatic reactions; determination of cell growth parameters; statistical analysis and model discrimination. (WHG)

Fogler, chapter 5.

"Theory and Practice of Biomolecular Measurements." Chapter 4 in Biological Kinetics.

R6Recitation 6
L13Biological reactors - chemostats. Theory of the chemostat. Fed batch or semi-continuous fermentor operation. (KDW)

Fogler, section 7.4.

"Cell Growth and Death." Chapter 7 in Biological Kinetics.

Midterm exam 1
R7Recitation 7: Review of midterm exam 1 and WebLab experiment
L14Kinetics of non-covalent bimolecular interactions. Significance; typical values and diffusion limit; approach to equilibrium; multivalency. (KDW)"Noncovalent Binding Interactions." Chapter 2 in Biological Kinetics.
L15Gene expression and trafficking dynamics. Approach to steady state; receptor trafficking. (KDW)"Binding Equilibria and Kinetics." Chapter 3 in Biological Kinetics.
R8Recitation 8
L16Catalysis. Inorganic and enzyme catalysts and their properties; kinetics of heterogeneous catalytic reactions; adsorption isotherms, derivation of rate laws; Langmuir-Hinshelwood kinetics. (WHG)Fogler, sections 10.1, 10.2, and 10.3.
L17Mass transfer resistances. External diffusion effects. Non-porous packed beds and monoliths, immobilized cells. (WHG)Fogler, sections 11.1, 11.2, and 11.3.
L18External mass-transfer resistance: Gas-liquid reactions in multiphase systems. (KDW)Fogler, section 11.3.
L19Oxygen transfer in fermentors. Applications of gas-liquid transport with reaction. (KDW)
R9Recitation 9
Midterm exam 2
L20Reaction and diffusion in porous catalysts. Effective diffusivity, internal and overall effectiveness factor, Thiele modulus, apparent reaction rates. (KDW)Fogler, sections 12.1, 12.2, 12.3, 12.4, and 12.5.
R10Recitation 10
L21Reaction and diffusion in porous catalysts (cont.). Packed Bed Reactors. (WHG)Fogler, sections 12.5 and 12.6.
L22Combined internal and external transport resistances. (WHG)Fogler, sections 8.9 and 12.7.
R11Recitation 11
L23Pulling it all together; applications to energy/chemicals industry. Presentation of current research. (WHG)
L24Pulling it all together; applications to bioengineering and medicine. Presentation of current research. (KDW)
R12Recitation 12
L25Course review. (WHG)
Final exam

Error in Fogler: Superficial Velocity or Actual Velocity (PDF)


 








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