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Molecular Principles of Biomaterials >> Content Detail



Lecture Notes



Lecture Notes

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LEC #TOPICSSLIDESANNOTATED
1

Overview of Course, Orientation to Current Approaches and Types of Molecularly-designed Biomaterials



Biodegradable Polymeric Solids


Chemistry and Physical Chemistry of Hydrolysis

Links between Materials Structure and Hydrolysis Mechanisms

(PDF - 1.6 MB)(PDF - 1.7 MB)#
2

Biodegradable Polymeric Solids (cont.)


Factors Controlling Polymer Degradation Rates

Theory of Solid Polymer Erosion

Tailoring Degradable Polymer Structure and Composition

(PDF)(PDF)#
3

Controlled Release Devices


Types of Controlled Release Devices

Degradable Materials in Controlled Release Devices

Physical Chemistry Principles in Delivering Small Molecules vs. Proteins

(PDF)(PDF)#
4

Controlled Release Devices (cont.)


Theory of Drug Release in Eroding Systems

(PDF)(PDF - 1.1 MB)#
5

Case Studies in Complex Controlled Release


Pulsatile Release from Programmed Eroding Systems

Controlled Release Microchips

Combining Drug Delivery with Tissue Engineering

6

Hydrogels as Biomaterials


Hydrogel Structure and Physical Chemistry

Methods of Polymerization

(PDF - 2.0 MB)
7

Hydrogels as Biomaterials (cont.)


Theory of Hydrogel Swelling

Physical Hydrogels

  • Ionic and Hydrogen Bonding in Gels
  • Association of Amphiphilic Block Copolymers
(PDF)(PDF)#
8

Hydrogels as Biomaterials (cont.)


Polyelectrolyte Hydrogels

Coacervates

Polyelectrolyte Multi-layers

(PDF)(PDF)#
9

Hydrogels as Biomaterials (cont.)


Theory of Polyelectrolyte Gel Swelling

(PDF - 1.1 MB)(PDF - 1.2 MB)#
10

Hydrogels as Biomaterials (cont.)


Applications of Hydrogels: Molecular Imprinting

Applications of Hydrogels: Glucose-sensitive Drug Delivery

Kinetics of Drug Diffusion through Hydrogels

(PDF - 1.1 MB)(PDF - 1.2 MB)#
11

Engineering Biological Recognition of Biomaterials


Biological Recognition in Vivo

Protein-resistant and Cell-resistant Surfaces

Engineering Recognition of Biomaterials: Adhesion and Migration

(PDF - 2.3 MB)(PDF - 1.8 MB)#
12

Engineering Biological Recognition of Biomaterials (cont.)


Enzymatic Recognition of Biomaterials

Cytokine Signaling from Biomaterials

(PDF - 1.8 MB)(PDF - 2.0 MB)#
13

Engineering Biological Recognition of Biomaterials (cont.)


Mimicking Cell-cell Contacts with Surfaces

(PDF - 2.9 MB)(PDF - 3.4 MB)#
14

Bioceramics and Biocomposites


Introduction to Biological Approaches to Biomineralization

Interfacial Biomineralization

(PDF - 1.6 MB)

(PDF - 2.2 MB)#

15

Bioceramics and Biocomposites (cont.)


Biological Control of Mineralization within Vesicles

Biomimetic Syntheses: Microemulsion and Micellar Reactions Organic Templating of Inorganic Biomaterials: Natural and Synthetic Approaches

(PDF)(PDF - 1.7 MB)#
16

Bioceramics and Biocomposites (cont.)


Theory of Controlled Nucleation

Bone Structure and Bone Biomimesis

Biocomposites in Device Applications and Drug Delivery

(PDF - 1.0 MB)(PDF - 2.2 MB)#
17

Molecular Devices


Molecular Switches via Proteins and 'Smart' Polymers

  • Temperature, pH, and Light-sensitive Switches

Molecular Motors

  • Kinesin-based Molecular Shuttles
  • ATP Synthase-based Nano-rotors
(PDF - 1.4 MB)(PDF - 1.5 MB)#
18

Nanoparticle and Microparticle Biomolecule Drug Carriers


Pro-drugs, Micelles, Liposomes, Polymerosomes, Nanoparticles, and Microparticles

Delivery of Drugs to Tissues via Systemic Circulation

Materials for Anti-Cancer Drug Delivery

(PDF - 4.1 MB)(PDF - 4.6 MB)#
19

Nanoparticle and Microparticle Biomolecule Drug Carriers (cont.)


Barriers to Systemic / Oral Delivery and Delivery of Molecules to Tissues

'Stealth' Particles

  • Theory of Protein-resistant Particles

Experimental Function of Long-circulating Carriers and PEGylated Compounds

(PDF - 2.0 MB)(PDF - 2.2 MB)#
Focus Topic: Integrating Biological Knowledge Into Biomaterials Design For Vaccines
20

Basic Biology of Vaccination and Viral Infections


Rudiments of Adaptive Immunity: The Basis of Vaccination

Viral Infections

(PDF)(PDF - 1.3 MB)#
21

Basic Biology of Vaccination and Viral Infections (cont.)


Vaccination Against Viruses: Parallels between Immunization and Infection

(PDF)(PDF - 1.5 MB)#
22

Drug Targeting and Intracellular Drug Delivery for Vaccines


Targeting Nano-carriers and Micro-carriers to Specific Cell Types

Chemistry of Antibodies for Targeting

Pathways of Intracellular Transport

(PDF)(PDF)#
23

Drug Targeting and Intracellular Drug Delivery for Vaccines (cont.)


Mechanisms of Intracellular Delivery

Mimicking Viral Entry Strategies

(PDF - 2.8 MB)(PDF - 3.1 MB)#
24

DNA Vaccines


Gene Therapy and DNA Immunization

Mechanisms of DNA Vaccines

(PDF - 4.1 MB)(PDF - 4.7 MB)#
25

DNA Vaccines (cont.)


Delivery Systems for DNA

Systemic vs. Local Delivery


 








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