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Macroepidemiology (BE.102) >> Content Detail



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Calendar

LEC #TOPICSKEY DATES
1Introduction: Dimensions of information available to define the unknown causes of common diseases
2Public health records and estimation of age-specific risk
3Effects of changes in diagnosis, prevention and therapy on historical mortality rates

Sources of differences in reported incidence and mortality
PS 1 due
4Mathematical models derived from histopathological observations and age-specific mortality/incidence data

Examples: lung and colorectal cancers
5Initiation
6Promotion and ProgressionTerm paper chapter 1 due
7Multiparametric Analysis of Colon Cancer
8Multiparametric Analysis of Lung CancerPS 3 due
9Role of Gender
10Sub-populations at Risk
11National Risk and Community Risk
12Familial Risk Expectations
13Familial Risk ObservationsTerm paper chapter 2 due
14Population Genetics
15Population Genetics (cont.)
16The search for genes carrying mutations conferring risk for common diseases
17The search for genes carrying mutations conferring risk for common diseases (cont.)
18The search for genes carrying mutations conferring risk for common diseases (cont.)Term paper chapter 3 due
19The search for genes carrying mutations conferring risk for common diseases (cont.)
20The search for genes in which mutations of initiation (and promotion, if any) occur in common human cancers
21The origins of somatic and inherited mutations in humans
22The origins of somatic and inherited mutations in humans (cont.)
23Hypotheses that need testingTerm paper chapter 4 due
24Evolution, embryogenesis and carcinogenesis (Guest lecturer: Dr. Elena V. Gostjeva)

Putting it together: Gostjeva-Thilly cascade model for risk and genesis of common clonal diseases
25-27General discussion and student presentationsFinal term paper due

 








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